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CME
Treating Depressive Disorders
 
"Anxious" Depression
Level of Evidence Place in Therapy Medication Usual Daily Dose1 Cost per
Day2
Level I Evidence and generally tolerable side effect/safety profile. 1st choice FLUOXETINE
(Prozac) 		20-40 mg $1.08-2.16
PAROXETINE
(Paxil) 		20-40 mg $1.59-3.18
SERTRALINE
(Zoloft) 		50-150 mg $1.60-3.35
NEFAZODONE
(Serzone) 		200-400 mg $0.93-1.86
VENLAFAXINE
(Effexor) 		75-225 mg $1.56-3.21
MOCLOBEMIDE
(Manerix) 		450-600 mg $1.22-2.28
Level II evidence or Level I evidence but less tolerable side effect/safety profile. 2nd choice FLUVOZAMINE
(Luvox) 		100-200 mg $0.99-1.98
IMIPRAMINE
(Tofranil) 		100-250 mg $0.04-0.09
AMITRIPTYLINE
(Elavil) 		100-250 mg $0.03-0.08
CLOMIPRAMINE
(Anafranil) 		100-250 mg $0.87-2.19

NOTE: Non-responding patients should be switched to an alternative 1st choice agent prior to attempting a 2nd choice antidepressant.

 

1. Usual daily doses are provided unless otherwise stated. Consult the drug monograph for details on age and condition specific dosing.
2. Approximate costs were derived from the ODB formulary (#36) or manufacturers' price lists and do not include professional fees or markups.

From: CANMAT - Guidelines for the Diagnosis and Pharmacological Treatment of Depression (1st Edition Rev., 1999) Page 20.

Back to Treating Depressive Disorders

Back to Managing Depressive Disorders - (Selections from: CANMAT - Guidelines for the Diagnosis and Pharmacological Treatment of Depression [1st Edition Rev., 1999])

 



Over one million Canadians suffer from some form of depressive illness.